What are the main sources of the genital system during development?

The genital system develops from three primary sources: intermediate mesoderm, part of the cloaca, and celomic epithelium.

When does morphological differentiation of the genital system begin and end?

Morphological differentiation starts at week 7 and is completed by week 20 of embryonic development.

What is the role of the SRY gene in genital development?

The SRY gene on the Y chromosome produces testis-determining factor (TDF), which triggers testis development. Without it, the default pathway leads to ovary formation.

What is the indifferent gonad, and when does it exist?

The indifferent gonad is a stage where gonads are identical in both sexes, existing up to week 6. It has an outer cortex and inner medulla, formed from the genital ridge.

How do primordial germ cells contribute to gonad development?

Primordial germ cells originate from the yolk sac wall during week 2, migrate to the genital ridges by week 5–6, and induce the formation of primitive sex cords in the indifferent gonad.

What structures form from the mesonephric duct in male development?

In males, the mesonephric duct develops into key structures: epididymis, vas deferens, seminal vesicle, and ejaculatory duct.

How does ovary development differ from testis development?

In ovary development, medullary cords regress and cortical cords form primordial follicles, with no tunica albuginea. In contrast, testis development involves medullary cords forming seminiferous tubules and a tunica albuginea.

Gonadal Development – Sex Determination & Differentiation

❓ Frequently Asked Questions